2-Furoicacid, tetrahydro-
2-Tetrahydrofuroic acid
CAS: 16874-33-2
Molecular Formula: C5H8O3
2-Furoicacid, tetrahydro- - Names and Identifiers
2-Furoicacid, tetrahydro- - Physico-chemical Properties
| Molecular Formula | C5H8O3 |
| Molar Mass | 116.12 |
| Density | 1.209g/mLat 25°C(lit.) |
| Melting Point | 21°C |
| Boling Point | 128-129°C13mm Hg(lit.) |
| Flash Point | 139 °C |
| Water Solubility | soluble |
| Vapor Presure | 0.0107mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear yellow to brown |
| BRN | 109671 |
| pKa | 3.60±0.20(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | n20/D 1.46(lit.) |
| Physical and Chemical Properties | Colorless to yellow viscous liquid, heat or long storage to Brown. Boiling point of 244 deg C (736mmHg), flash point of 139 deg C. The relative density was 1.1700. Soluble in water, chloroform, ethyl acetate, etc. |
| Use | Used as a pharmaceutical Intermediate |
2-Furoicacid, tetrahydro- - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R22 - Harmful if swallowed R34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28A - |
| UN IDs | UN 3265 8/PG 3 |
| WGK Germany | 3 |
| HS Code | 29321900 |
| Hazard Class | 8 |
| Packing Group | III |
2-Furoicacid, tetrahydro- - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | 2-tetrahydrofuran carboxylic acid (tetrahydrofuran-2-carboxylic acid, 2-THFA), respectively, after resolution (R)-2-THFA and (S)-2-THFA, chiral 2-tetrahydrofurancarboxylic acid are important ligand synthons in asymmetric synthesis reactions. (R)-2-THFA is an important intermediate for the synthesis of the antibiotic furopenem, which can be used as an antagonist of antigen VLA-4, and is also an important intermediate of the super influenza drug Xofluza. 2-THFA is the main raw material for the preparation of chiral auxiliary (S)-acetyl Tetrahydrofuran, is the raw material for the preparation of cephalosporin antibiotic intermediates, and is also an important intermediate for the preparation of hormone releasing hormone LHRH. pharmaceutical synthesis intermediates. for pharmaceutical intermediates |
Last Update：2024-04-09 20:52:54
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